WebDec 31, 1997 · Semantic Scholar extracted view of "Chemistry, biochemistry and biology of sialic acids☆" by R. Schauer et al. Semantic Scholar extracted view of "Chemistry, ... “In … Sialic acids are a class of alpha-keto acid sugars with a nine-carbon backbone. The term "sialic acid" (from the Greek for saliva, σίαλον - síalon) was first introduced by Swedish biochemist Gunnar Blix in 1952. The most common member of this group is N-acetylneuraminic acid (Neu5Ac or NANA) found in animals and … See more The sialic acid family includes many derivatives of the nine-carbon sugar neuraminic acid, but these acids rarely appear free in nature. Normally they can be found as components of oligosaccharide … See more Sialic acid containing glycoproteins (sialoglycoproteins) bind selectin in humans and other organisms. Metastatic cancer cells often express a high density of sialic acid-rich … See more Sialic acids are found at all cell surfaces of vertebrates and some invertebrates, and also at certain bacteria that interact with vertebrates. See more Rat pups supplemented with sialic acid showed improved learning and memory as adults. A relationship between dietary sialic acid supplementation and cognitive function was seen in piglets that had been fed high doses of sialic acid. See more Sialic acid is synthesized by glucosamine 6 phosphate and acetyl-CoA through a transferase, resulting in N-acetylglucosamine-6-P. This becomes N-acetylmannosamine-6-P through epimerization, which reacts with phosphoenolpyruvate producing … See more The synthesis and degradation of sialic acid are distributed in different compartments of the cell. The synthesis starts in the cytosol, where N-acetylmannosamine 6 … See more Sialic acids are related to several different diseases observed in humans. Sialic acid deficiency with mutations in the NANS gene Biallelic recessive mutations in the sialic acid synthesis gene, N-acetyl-neuraminic acid synthase … See more

Exploration of the Sialic Acid World - PubMed

WebSialic acid structure is an alpha- keto acid sugar with a skeletal of nine Carbon atoms, which is obtained from a molecule, neuraminic acid by replacing with amino group of one of its … WebNative insulin is susceptible to biophysical aggregation and fibril formation, promoted by manual agitation and elevated temperatures. The safety of the drug and its application to alternative forms of administration could be enhanced through the identification of chemical modifications that strengthen its physical stability without compromising its biological … greenspan financial services

Glycomics studies using sialic acid derivatization and …

WebJan 17, 2024 · Exploration of sialic acid world Chapter 1, Advances in carbohydrate chemistry and biochemistry, vol. 75, 2024, Elsevier. Modifications to core structures of sialic acid by O -acetylation, O -methylation, or introduction of O -lactyl groups, sulfate, or phosphate esters at positions 4, 7, 8, and/or 9, generated by enzymes, have been reported. WebSep 8, 2024 · A drug-resistant replication-defective influenza virus is constructed by means of using the characteristic of segmentation of the influenza virus genome in combination with a gene codon extension technique, and a new anti-influenza virus treatment method is established. According to the known genome sequence of the drug-resistant influenza … WebFeb 18, 2024 · Sialic acids cap the glycans of cell surface glycoproteins and glycolipids. They are involved in a multitude of biological processes, and aberrant sialic acid … greenspan eyecare parsippany nj