Webb5 nov. 2024 · We hypothesized that moderate impairment of PU.1 abundance, as found in AML, can cooperate with loss-of-function mutations of Tet2 to initiate malignancy. We … Webb16 nov. 2008 · Hsp90 inhibition by PU-H71 in DLBCL was associated with the destabilization and subsequent degradation of several onco-proteins such as Akt, c-Raf and IKK/Nemo, thus affecting the activity of many oncogenic pathways. To evaluate the in vivo anti-lymphoma effect of PU-H71, OCI-Ly7, Farage and SUDHL4 xenografted …
Antitumor Efficacy of the Purine-Scaffold Hsp90 Inhibitor PU-H71 …
WebbFinally, PU.1 inhibition reduced the atrial fibrosis induced by Ang-II and attenuated vulnerability to AF, at least in part through the TGF-β1/Smads pathway. Overall, the … Webb15 dec. 2013 · We noted that inhibition of HSP90 with PU-H71 led to upregulation of HSP70 and HSP27 in a dose dependent manner suggesting a compensatory increase in co-chaperones. Using gene expression analysis from cell lines and patient samples, it has been shown that multiple signaling pathways involved in proliferation, cell cycle … newgard locks
PU.1 inhibition does not attenuate cardiac function deterioration …
Webb1 dec. 2024 · In murine and human AML (xeno)transplantation models, treatment with our PU.1 inhibitors decreased tumor burden and resulted in increased survival. Thus, our study provides proof of concept that PU.1 inhibition has potential as a therapeutic strategy for the treatment of AML and for the development of small-molecule inhibitors of PU.1. Webb13 apr. 2016 · PU.1 binding was consistent with DB270's poor inhibitory efficacy of PU.1 in vivo, while its isosteric selenophene analog (DB1976), which did not bind PU.1 and … Webbor PU.. As expected the E bHLH domain mediated homodimerization with E. e bHLH domain also pulled down PU. demonstrating that it is su cient for mediating the interactionwith PU. (Figure (b)). To identify the domain of PU. that interacts with E, in vitro translated deletion products of PU. were incubated with puri ed GST-E bHLH protein ... new garden town square