Curis ca-4948 nhl ash presentation 2020
WebNov 4, 2024 · As part of this collaboration, Curis has exclusive licenses to oral small molecule antagonists of immune checkpoints including, the VISTA/PDL1 antagonist CA-170, and the TIM3/PDL1 antagonist CA ... WebNov 13, 2024 · A phase 1 trial in patients with NHL is being conducted to determine safety, pharmacokinetics, and preliminary efficacy of CA-4948 as monotherapy. Patients and Methods. At the 18-Jul-2024 data cut-off date, 22 patients have been treated with single-agent CA-4948.
Curis ca-4948 nhl ash presentation 2020
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WebMay 12, 2024 · First Quarter 2024 Financial Results. For the first quarter of 2024, Curis reported a net loss of $9.9 million or $0.11 per share on both a basic and diluted basis, as compared to a net loss of $9 ... WebNov 5, 2024 · Both dose are safe and active against NHL as seen in the nearly completed monotherapy Part A1 of this trial Patients will receive CA-4948 with ibrutinib at the labeled dose for the respective NHL subtype (560 mg or 420 mg) until toxicity or progression.
WebCA-4948 is a novel oral IRAK4 inhibitor of the TLR/myddosome Pathway • Well absorbed; pharmacokinetics are predictable and support BID dosing • Well tolerated; safety profile allows long-term treatment and combination with other active drugs against NHL • Pharmacodynamic analyses demonstrate NFκB inhibition and reduction of cytokine release WebCA-4948 is the most advanced IRAK4 inhibitor in clinical development for cancer CA-4948 inhibits IRAK4 and several additional key oncogenic targets CA-4948 binding affinity % Inhibition at 0.1 nM Illustration reproduced courtesy of Cell Signaling Technology 7 DiscoverX Kinase Panel (378 kinases screened) In Nov 2024, the NCI selected CA-4948 ...
WebMar 16, 2024 · As of December 31, 2024, Curis' cash, cash equivalents and investments totaled $183.1 million, which includes net proceeds of $159.1 million from our follow-on public offering in December... WebMay 12, 2024 · Curis Reports Updated Data in Two Abstracts for CA-4948 Accepted for Presentation at the European Hematology Association 2024 Virtual Congress /PRNewswire/ -- Curis, Inc. (NASDAQ: CRIS),...
WebMay 13, 2024 · Curis, whose market cap now sits at nearly $1.5bn, has a lot riding on CA-4948. Its next most advanced asset is the anti-Vista monoclonal antibody CI-8993, on which phase 1 data is due in the second half of the year. Two further clinical-stage assets are on ice after earlier disappointments.
WebDec 7, 2024 · Curis slumps ( CRIS -25.0%) as investors seem to be disappointed on updated data from its ongoing Phase 1 study evaluating of CA-4948, an IRAK4 kinase inhibitor, for the treatment of relapsed... ionia michigan public schoolsWebNov 6, 2024 · As part of this collaboration, Curis has exclusive licenses to oral small molecule antagonists of immune checkpoints including, the VISTA/PDL1 antagonist CA-170, and the TIM3/PDL1 antagonist CA ... ontario quilt showWebDec 23, 2024 · On December 8th, 2024 on the heels of the clinical trial data released for NHL, Curis released encouraging phase 1 trial data for CA-4948 in the treatment of relapsed and refractory... ontario quick access breacherWebMar 1, 2024 · Figure 2: Pipeline (Source: corporate presentation) CA-4948 goes after IRAK4 (first in class inhibitor) and CI-8993 is a monoclonal antibody first in class antagonist of VISTA (the third of 3 ... ontario quilt showsWebThis presentation contains certain forward-looking statements about Curis, Inc. (“we,” “us,” or the “Company”) within the meaning of the Private Securities Litigation Reform ... (NHL) CA-4948* IRAK4 IRAK4L-expressing Leukemia (AML/MDS) Fimepinostat HDAC/PI3K MYC-altered ... In Nov 2024, the NCI selected CA-4948, Curis’s first-in ... ionia michigan city managerWebCA-4948 is the first clinical candidate targeting IRAK4 to be evaluated in cancer patients. Here we present Phase I results of CA-4948 in patients with relapsed/refractory hematologic malignancies. Method CA-4948-101 is a phase I trial dose escalation trial with a … ionia michigan register of deedsionia michigan chamber of commerce